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  • G-quadruplexes are transcription factor binding hubs

    2021-4-23 · The binding of transcription factors (TF) to genomic targets is critical in the regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely implicated in TF recruitment, but many questions remain on how binding site specificity is governed. Herein, we reveal a previously unappreciated role for DNA secondary structures as key features for TF recruitment.

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  • Grasshopper - algorithmic modeling for Rhino

    For designers who are exploring new shapes using generative algorithms, Grasshopper® is a graphical algorithm editor tightly integrated with Rhino’s 3-D modeling tools. Unlike RhinoScript, Grasshopper requires no knowledge of programming or scripting, but still allows designers to build form generators from the simple to the awe-inspiring.

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  • Ferrari Model List: Every Ferrari, Every Year

    2020-11-20 · Graphs are commonly used for representing complex structures such as social relationships, biological interactions, and knowledge bases. In many scenarios, graphs not only represent topological relationships but also store the attributes that denote the semantics associated with their vertices and edges, known as attributed graphs. Attributed graphs can meet demands for a wide …

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  • A phylogenomic data-driven exploration of viral

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  • A review of dynamical systems approaches for the

    2021-4-9 · An example would be the theoretical models of single TF oscillations mapped by Heltberg et al.,5 exhibiting the self-organization of strange attractors (beyond a critical threshold). The key concept to understand here is the universality of attractors in dynamical systems. ... We shall not get into the finer details of these approaches herein ...

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  • Modeling tissue-specific signaling and organ function

    2003-6-15 · However, the idea that understanding these connections requires 3D models is now being more widely championed. Commenting on recent papers by Debnath et al. and Weaver et al., Jacks and Weinberg conclude:“Suddenly, the study of cancer cells in two dimensions seems quaint, if not archaic” ( Debnath et al.,2002 ; Weaver et al.,2002 ; Jacks ...

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  • A phylogenomic data-driven exploration of viral

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    2020-12-15 · 1. Introduction. Limiting the damage from climate change is a major challenge facing the global economy. The Paris Accord aims to curb emissions of Carbon Dioxide (CO2) and other Greenhouse Gases (GHGs) in an attempt to keep the average temperature rise under 1.5°C , .Meeting these ambitious goals will require mass adoption of environmental technologies such as renewable …

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  • The EV revolution: The road ahead for critical raw ...

    The Parabolic SAR indicator and certain technical details are used to ensure the most accurate entries. The EA is highly customizable. It is recommended for simultaneous use on 4 currency pairs: EURUSD M15; GBPUSD M15; USDJPY M15; USDCAD M15. Despite good stability, it is advisable to disable the EA operation during the days rich in news releases.

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  • Systems Analysis of Thrombus Formation | Circulation

    2016-5-2 · Typically for TF-triggered clotting of flowing whole blood on a collagen surface, platelet accumulation will lead to dense deposits that grow >60-μm thick within 300 seconds with fibrin forming subsequently after 1 to 2 minutes in a location close to the surface where the TF and thrombin resides in the experiment. 99,101,102,108 More ...

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    3M™ Versaflo™ Powered Air Purifying Respirator Painters Kit TR-800-PSK/94248 (AAD), 1 EA/Case. Buying options. 3M™ Versaflo™ Healthcare PAPR Kit TR-300N+ HKL, Medium - Large 1 EA/Case. Buying options. 3M™ Versaflo™ Headcover with Integrated Head Suspension, S-133L-5, White, Medium/Large, 5 EA/Case. Buying options.

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    The strong functionality conservation of another TF, MAX, and its left-skewed enrichment in the K562 cell line can be found in Supplementary Figure S4. An extended investigation of the 248 undocumented motifs showed that they are likely to be cis -regulatory elements having similar functionalities as known motifs, but have not been ...

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  • Prediction of regulatory motifs from human Chip

    Ligase concentration was varied as a function of phasing length (0.3 U/μl for the in-phase 156L14 and 156L16 constructs and 1.2 U/μl for all other phasing constructs) and total length (from 0.2 U/μl for the 157 constructs, to 0.8 U/μl for the 154–155 and 158–160 constructs and 2.2 U/μl for the 150–153 constructs).

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  • complex architecture of p53 binding sites | Nucleic

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    The Parabolic SAR indicator and certain technical details are used to ensure the most accurate entries. The EA is highly customizable. It is recommended for simultaneous use on 4 currency pairs: EURUSD M15; GBPUSD M15; USDJPY M15; USDCAD M15. Despite good stability, it is advisable to disable the EA operation during the days rich in news releases.

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    Suez Canal blocked by container ship. verymadmac (Mechanical) (OP) 25 Mar 21 06:38. It might not be an engineering issue that started it, but I bet is going to change a few specifications. BBC piece here Link. It looks like the bow is hard aground, refloating will be an interesting exercise given the time pressure. Canal profile is here.

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  • Navigating in foldonia: Using accelerated molecular ...

    2017-3-22 · The β roll molecules with sequence (GAGAGAGQ) 10 stack via hydrogen bonding to form fibrils which have been themselves been used to make viral capsids of DNA strands, supramolecular nanotapes and pH-responsive gels. Accelerated molecular dynamics (aMD) simulations are used to investigate the unfolding of a stack of two β roll molecules, (GAGAGAGQ) 10, to shed light on the …

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  • Optimal-Transport Analysis of Single-Cell Gene

    In Waddington’s metaphor, the reprogrammed cells roll through a rich landscape of valleys. Ultimately, the analysis of natural and artificial trajectories has much to teach us about the genetic circuits that control organismal development and regulate cellular homeostasis.

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  • Prediction of regulatory motifs from human Chip

    The strong functionality conservation of another TF, MAX, and its left-skewed enrichment in the K562 cell line can be found in Supplementary Figure S4. An extended investigation of the 248 undocumented motifs showed that they are likely to be cis -regulatory elements having similar functionalities as known motifs, but have not been ...

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  • The case for an HIV cure and how to get there - The

    2020-11-30 · In light of the increasing global burden of new HIV infections, growing financial requirements, and shifting funding landscape, the global health community must accelerate the development and delivery of an HIV cure to complement existing prevention modalities. An effective curative intervention could prevent new infections, overcome the limitations of antiretroviral treatment, …

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  • Quantitatively assessing mekosuchine crocodile

    2019-12-19 · Morphological shifts observed in the fossil record of a lineage potentially indicate concomitant shifts in ecology of that lineage. Mekosuchine crocodiles of Cenozoic Australia display departures from the typical eusuchian body-plan both in the cranium and postcranium. Previous qualitative studies have suggested that these crocodiles had a more terrestrial habitus than extant …

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    Suez Canal blocked by container ship. verymadmac (Mechanical) (OP) 25 Mar 21 06:38. It might not be an engineering issue that started it, but I bet is going to change a few specifications. BBC piece here Link. It looks like the bow is hard aground, refloating will be an interesting exercise given the time pressure. Canal profile is here.

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